1.
Int J Rheum Dis
; 2022 Nov 13.
Article
in English
| MEDLINE | ID: covidwho-2246787
ABSTRACT
Leflunomide is a classic disease-modifying anti-rheumatic drug that is widely used to treat autoimmune diseases. Studies also show its antiviral effects in in vitro and/or in vivo experiments. Considering glucocorticoids, immunosuppressants and newly emerged antibodies commonly used in autoimmune diseases and autoinflammatory disorders bring risk of infection such as viral infection, leflunomide with combination of anti-viral and immunosuppressive features to maintain the balance between infection and anti-inflammation are attractive. Here we summarize the actions and mechanisms of leflunomide in immunoregulatory and antiviral effects.
2.
Ann Rheum Dis
; 81(7): 1050-1052, 2022 07.
Article
in English
| MEDLINE | ID: covidwho-1923162